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Supercharge Claude with Authoritative Compliance Data

Supplement Your Claude Cowork Experience with Real-Time Regulatory Intelligence

The OrchestraPrime MCP Server is a Claude-native integration that brings authoritative regulatory intelligence directly into your Claude conversations. It extends Claude's capabilities through the Model Context Protocol (MCP) – the same open standard used by Anthropic's own Knowledge Work Plugins marketplace.

What You Can Do​

Instead of switching between Claude and external compliance databases, you can now:

  • Search FDA, ICH, EMA, WHO, and CDISC regulations using natural language
  • Get citable sources – not AI-generated summaries, but actual regulatory citations with URLs
  • Build evidence chains with confidence scores for audit trails

How This Fits the Claude Plugin Ecosystem​

Anthropic's Knowledge Work Plugins marketplace defines 11 plugin categories for enterprise productivity. CTWise MCP aligns with and enhances these:

Marketplace CategoryCTWise Enhancement
LegalContract compliance research, CDS classification, ICH GCP verification
Bio ResearchFDA/ICH guidance search, CMC requirements, clinical trial protocol compliance

What Makes This Complementary: Unlike knowledge plugins that synthesize information from training data, CTWise provides grounded responses from authoritative data sources with:

  • Confidence Scores (0-100%) for relevance
  • Citable URLs to primary regulatory sources
  • Real-Time Data refreshed daily from official government sources

Video Tutorials​

Quick Start Demo (90 seconds)​

See the OrchestraPrime MCP Server in action — from installation to live regulatory search in Claude Desktop:

Conceptual Deep Dive (3 minutes)​

Understand the MCP architecture and how authoritative compliance data flows from government sources into Claude:

Getting Started​

Prerequisites​

Installation​

The OrchestraPrime MCP Server is published on npm and the official MCP Registry. Install with a single command:

npx @orchestraprime/mcp-server

That's it — no git clone, no build steps. npx downloads and runs the latest version automatically.

Configure Claude Desktop​

Edit the configuration file:

macOS: ~/Library/Application Support/Claude/claude_desktop_config.json Windows: %APPDATA%\Claude\claude_desktop_config.json

{
  "mcpServers": {
    "orchestraprime": {
      "command": "npx",
      "args": ["@orchestraprime/mcp-server"],
      "env": {
        "CTWISE_API_KEY": "ctw_YOUR_API_KEY_HERE"
      }
    }
  }
}

Restart Claude Desktop and look for the hammer/tools icon.

Example Usage​

Natural Language Queries​

You don't need to specify tool names. Just ask naturally:

Your QuestionClaude Automatically Uses
"What FDA requirements apply to AI diagnostic software?"search_regulations
"What are the ICH GCP requirements for sponsor obligations?"search_regulations
"Does my CDS software need FDA clearance?"check_cds_classification
"What regulatory updates came out this week?"get_recent_updates

Sample Conversation​

You: What FDA requirements apply to AI-powered diagnostic software?

Claude: I'll search the regulatory database for FDA requirements on AI diagnostic software.

[Using search_regulations tool...]

Based on the CTWise regulatory search, here are the key FDA requirements:

1. **Clinical Decision Support Software Guidance** (2022-09-28)
   - Source: FDA
   - Relevance Score: 94%
   - URL: https://www.fda.gov/regulatory-information/...

2. **Artificial Intelligence and Machine Learning in SaMD** (2023-04-03)
   - Source: FDA
   - Relevance Score: 91%
   - URL: https://www.fda.gov/medical-devices/...

Available Tools​

ToolDescription
search_regulationsSemantic search across FDA, ICH, EMA, WHO, CDISC
get_rule_detailsGet full rule text and citations
list_sourcesList available data sources
check_cds_classificationCDS 4-criteria analysis
check_protocol_complianceICH GCP verification
get_recent_updatesLatest regulatory changes

Learn More​