Pricing Tiers

CTWiseAPI offers flexible pricing tiers to match your usage needs.

Tier Comparison

Feature	Free	Starter
Price	$0/month	$99/month
API Calls	1,000/month	10,000/month
Rate Limit	2/second	10/second
Search Results	Top 5	Full results
Evidence Chains	Summary only	Complete chains
Sources	FDA only	FDA + ICH + EMA
JSON Export	❌	✅
Confidence Scores	❌	✅
Test API Keys	❌	✅
Priority Support	❌	❌

Tier Details

Free Tier

Perfect for evaluation and small projects.

• 1,000 API calls/month
• 2 requests/second rate limit
• Access to FDA regulatory content
• Top 5 results per search
• Summary-level evidence chains
• Email support

Try Before You Buy

The Free tier is great for evaluating CTWiseAPI before committing to a paid plan.

Starter Tier

For teams actively using regulatory intelligence.

• 10,000 API calls/month
• 10 requests/second rate limit
• Full access to FDA, ICH, and EMA content
• Unlimited results per search
• Complete evidence chains with citations
• AI-powered confidence scores
• JSON export for integrations
• Test API keys for development
• Email support (24-hour response)

Feature Details

Search Results

Tier	Behavior
Free	Returns top 5 most relevant results
Starter	Returns all matching results (paginated)

Evidence Chains

Tier	Behavior
Free	Returns a brief summary of the source
Starter	Returns complete document hierarchy with citations

Free Tier Response:

{
  "evidenceChain": "From 21 CFR Part 50 - Protection of Human Subjects"
}

Starter Tier Response:

{
  "evidenceChain": [
    {
      "level": 1,
      "title": "21 CFR Part 50 - Protection of Human Subjects",
      "section": "50.25",
      "url": "https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-50"
    },
    {
      "level": 2,
      "title": "Subpart B - Informed Consent of Human Subjects",
      "section": "50.20-50.27"
    }
  ]
}

Regulatory Sources

Source	Free	Starter
FDA Guidance	✅	✅
ICH Guidelines	❌	✅
EMA Regulations	❌	✅
WHO Standards	❌	✅

Confidence Scores

Starter tier includes AI-generated confidence scores (0.0 to 1.0) indicating how well each result matches your query:

{
  "ruleId": "rule_fda_001",
  "title": "21 CFR 50.25 - Elements of Informed Consent",
  "confidence": 0.95
}

Rate Limits

Tier	Requests/Second	Monthly Calls
Free	2	1,000
Starter	10	10,000

Rate Limit Exceeded

Exceeding rate limits returns 429 Too Many Requests. See Rate Limits for handling strategies.

Overage Policy

Free Tier

• API calls are blocked after 1,000 monthly calls
• Upgrade to Starter to continue

Starter Tier

• Soft limit: Warning at 80% usage
• Hard limit: API calls blocked at 10,000
• Contact sales for higher limits

Upgrading

Free → Starter

1. Sign in to app.orchestraprime.ai
2. Navigate to Settings → Billing
3. Click "Upgrade to Starter"
4. Complete AWS Marketplace checkout
5. New limits apply immediately

Need More?

For usage beyond 10,000 calls/month:

• Contact Sales: sales@ctwise.ai
• Custom Enterprise Plans: Coming Q2 2025

FAQ

When does my usage reset?

Usage resets on the 1st of each month at 00:00 UTC.

Can I switch between tiers?

Yes! You can upgrade or downgrade at any time through the dashboard.

What happens if I exceed my limit?

• Free tier: API returns 429 Quota Exceeded
• Starter tier: API returns 429 Quota Exceeded

Plan ahead with usage alerts (set in Dashboard → Settings).

Is there an annual discount?

Annual plans coming soon! Contact sales@ctwise.ai for early access.